RT Journal Article
T1 Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels
A1 Demelo Rodríguez, Pablo
A1 Cervilla Muñoz, Eva
A1 Ordieres Ortega, Lucía
A1 Parra Virto, A.
A1 Toledano Macías, M.
A1 Toledo Samaniego, N.
A1 García García, A.
A1 García-Fernández-Bravo, I.
A1 Ji, Z.
A1 Miguel Díez, Javier De
A1 Álvarez-Sala Walther, Luis Antonio
A1 Toro Cervera, Jorge Del
A1 Galeano Valle, Francisco
AB AimAn increased risk of venous thromboembolism (VTE) in patients with COVID-19 pneumonia admitted to intensive care unit (ICU) has been reported. Whether COVID-19 increases the risk of VTE in non-ICU wards remains unknown. We aimed to evaluate the burden of asymptomatic deep vein thrombosis (DVT) in COVID-19 patients with elevated D-dimer levels.MethodIn this prospective study consecutive patients hospitalized in non-intensive care units with diagnosis of COVID-19 pneumonia and D-dimer > 1000 ng/ml were screened for asymptomatic DVT with complete compression doppler ultrasound (CCUS). The study was approved by the Institutional Ethics Committee.ResultsThe study comprised 156 patients (65.4% male). All but three patients received standard doses of thromboprophylaxis. Median days of hospitalization until CCUS was 9 (IQR 5–17). CCUS was positive for DVT in 23 patients (14.7%), of whom only one was proximal DVT. Seven patients (4.5%) had bilateral distal DVT. Patients with DVT had higher median D-dimer levels: 4527 (IQR 1925-9144) ng/ml vs 2050 (IQR 1428-3235) ng/ml; p < 0.001. D-dimer levels > 1570 ng/ml were associated with asymptomatic DVT (OR 9.1; CI 95% 1.1–70.1). D-dimer showed an acceptable discriminative capacity (area under the ROC curve 0.72, 95% CI 0.61–0.84).ConclusionIn patients admitted with COVID-19 pneumonia and elevated D-dimer levels, the incidence of asymptomatic DVT is similar to that described in other series. Higher cut-off levels for D-dimer might be necessary for the diagnosis of DVT in COVID-19 patients.
PB Elsevier
SN 0049-3848
YR 2020
FD 2020-09
LK https://hdl.handle.net/20.500.14352/129432
UL https://hdl.handle.net/20.500.14352/129432
LA eng
NO 29.	Demelo-Rodríguez P, Cervilla-Muñoz E, Ordieres-Ortega L, Parra-Virto A, Toledano-Macías M, Toledo-Samaniego N, García-García A, García-Fernández-Bravo I, Ji Z, de-Miguel-Diez J, Álvarez-Sala-Walther LA, del-Toro-Cervera J, Galeano-Valle F. Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels. Thromb Res. 2020 Aug;192:23-26. doi: 10.1016/j.thromres.2020.05.018. Epub 2020 May 13.
DS Docta Complutense
RD 27 feb 2026