RT Journal Article
T1 Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California
A1 Escobedo-Ruíz, Araceli
A1 Barquera, Rodrigo
A1 González-Martín, Antonio
A1 Argüelles-San Millán, Juan Manuel
A1 Uribe-Duarte, María Guadalupe
A1 Iraíz Hernández-Zaragoza, Diana
A1 Clayton, Stephen
A1 Arrieta-Bolaños, Esteban
A1 Ruíz  Corral, María de Jesús
A1 Goné-Vázquez, Isis
A1 Arellano-Prado, Francia Paulina
A1 Martínez-Álvarez, Julio César
A1 García-Arias, Víctor Eduardo
A1 Rodríguez-López, Marla Estefanía
A1 Bravo-Acevedo, Alicia
A1 Sánchez-Fernández, María Guadalupe de Jesús
A1 Aguilar-Campos, Jesús Abraham
A1 Gómez-Navarro, Benjamín
A1 Sandoval-Sandoval, Mario J.
A1 Serrano-Osuna, Ricardo
A1 Yunis, Edmond J.
A1 Zúñiga, Joaquín
A1 Bekker-Méndez, Carolina
A1 Granados, Julio
AB We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes for the Baja California region include nine Native American and five European haplotypes. Admixture estimates revealed that the main genetic components are European (50.45 ± 1.84% by ML; 42.03% of European haplotypes) and Native American (43.72 ± 2.36% by ML; 40.24% of Native American haplotypes), while the African genetic component was less apparent (5.83 ± 0.98% by ML; 9.36% of African haplotypes).
PB Elsevier
SN 0198-8859, ESSN: 1879-1166
YR 2019
FD 2019-06-11
LK https://hdl.handle.net/20.500.14352/13846
UL https://hdl.handle.net/20.500.14352/13846
LA eng
DS Docta Complutense
RD 27 abr 2024