%0 Journal Article
%A Fernández Lucas, Alberto Amable
%A López-Ibor Alcocer, María Inés
%A Turrero Nogués, Agustín
%A Santos García, Juan Matías
%A Morón, María Dolores
%A Hornero, Roberto
%A Gómez, Carlos
%A Méndez, María Andreina
%A Ortiz Alonso, Tomás
%A López-Ibor Aliño, Juan José
%T Lempel-Ziv complexity in schizophrenia: A MEG study
%D 2011
%@ 1388-2457
%U https://hdl.handle.net/20.500.14352/44635
%X Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42. years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42. years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the " normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.
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