RT Journal Article
T1 Lempel-Ziv complexity in schizophrenia: A MEG study
A1 Fernández Lucas, Alberto Amable
A1 López-Ibor Alcocer, María Inés
A1 Turrero Nogués, Agustín
A1 Santos García, Juan Matías
A1 Morón, María Dolores
A1 Hornero, Roberto
A1 Gómez, Carlos
A1 Méndez, María Andreina
A1 Ortiz Alonso, Tomás
A1 López-Ibor Aliño, Juan José
AB Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42. years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42. years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the " normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.
PB Elsevier
SN 1388-2457
YR 2011
FD 2011-11
LK https://hdl.handle.net/20.500.14352/44635
UL https://hdl.handle.net/20.500.14352/44635
LA eng
NO Fernández, A. A., López Ibor, M. I., Turrero, A. et al. «Lempel–Ziv Complexity in Schizophrenia: A MEG Study». Clinical Neurophysiology, vol. 122, n.o 11, noviembre de 2011, pp. 2227-35. DOI.org (Crossref), https://doi.org/10.1016/j.clinph.2011.04.011.
NO Fundación Mutua Madrileña
DS Docta Complutense
RD 11 abr 2025