RT Journal Article
T1 gd T lymphocytes in the diagnosis of human T cell receptorimmunodeficiencies
A1 Garcillán Goyoaga, Beatriz de
A1 Marín Marín, Ana Victoria
A1 Jiménez Reinoso, Anaïs
A1 Briones Contreras, Alejandro
A1 Muñoz Ruiz, Miguel
A1 García León, María J
A1 Gil Calle, Juana Nelly
A1 Allende Martínez, Luis Miguel
A1 Martínez Naves, Eduardo
A1 Toribio, Maria Luisa
A1 Regueiro González-Barros, José Ramón
AB Human T cell receptor (TCR) immunodeficiencies (TCRID) are rare autosomal recessive disorders caused by mutations affecting TCR, CD3, or CD247 chains, which share developmental, functional, and TCR expression defects (1).Their rapid diagnosis is fundamental for patient survival and early hematopoietic stemcell transplantation.Here,we propose that studying gd T cells, which are often neglected, can be helpful for a timely diagnosis. We thus offer a diagnostic flowchart and some lab tricks based on published cases.
PB Frontiers Media
SN 1664-3224
YR 2015
FD 2015-06-25
LK https://hdl.handle.net/20.500.14352/23905
UL https://hdl.handle.net/20.500.14352/23905
LA eng
NO Ministerio de Economia y Competitividad (MINECO)
NO Insituto de Salud Carlos III (ISCIII)
NO Comunidad de Madrid
NO Fundación Lair
DS Docta Complutense
RD 19 abr 2025