RT Journal Article
T1 Predictive factors of hepatitis C virus eradication after interferon-free therapy in HIV coinfection
A1 Domínguez Domínguez, Lourdes
A1 Bisbal, Otilia
A1 Matarranz, Mariano
A1 Lagarde, María
A1 Pinar, Óscar
A1 Hernando, Asunción
A1 Lumbreras Bermejo, Carlos Juan
A1 Rubio, Rafael
A1 Pulido Ortega, Federico
AB Real-life cohorts have shown that the effectiveness of all-oral, direct-acting antivirals (DAA) for HCV treatment is > 90%. We aimed to explore the predictive factors of DAA success in HIV coinfection. This is an observational prospective study within the cohort "VIH-DOC", Madrid, Spain. HIV/HCV-coinfected patients were included if they had been treated with DAAs between 9 January 2015 and 31 August 2016. The sustained virological response (SVR) was analysed in the intention-to-treat population. Binary logistic regression was used to study the impact of cirrhosis, anti-HCV therapy experience and the IL28B polymorphism on SVR, besides factors with a p value < 0.15 from the univariate analysis. DAA were prescribed to 423 patients. SVR was confirmed in 92.9%. The univariate analysis showed higher proportion of patients with SVR among those with DAA adherence ≥ 95% (difference + 10.3%, 95% CI 3.5-19.6) and a baseline CD4+ cell count ≥ 200/μL (difference + 14.7%, 95% CI 4.1-31.0). Logistic regression evinced that both DAA adherence and baseline CD4+ cell counts predicted the SVR (OR 3.9, 95% CI 1.8-8.8, and OR 5.2, 95% CI 1.9-13.9, respectively). Moreover, men who reported having sex with other men (MSM) were less likely to achieve SVR (OR 4.2, 95% CI 1.1-16.1). Among MSM, three of three patients without SVR were suspected to have experienced HCV reinfection. DAA for HCV in HIV-coinfected patients is highly effective. DAA adherence ≥ 95% and a baseline CD4+ count ≥ 200/μL predicted a higher probability of SVR. A lower rate of SVR was found in MSM, presumably due to a higher frequency of HCV reinfection.
PB Springer
SN 0934-9723
YR 2019
FD 2019-01-28
LK https://hdl.handle.net/20.500.14352/105895
UL https://hdl.handle.net/20.500.14352/105895
LA eng
NO Domínguez-Domínguez, L., Bisbal, O., Matarranz, M. et al. Predictive factors of hepatitis C virus eradication after interferon-free therapy in HIV coinfection. Eur J Clin Microbiol Infect Dis 38, 725–734 (2019). https://doi.org/10.1007/s10096-019-03488-0
DS Docta Complutense
RD 9 abr 2025