%0 Journal Article
%A Huntley, Dixie
%A Giménez, Estela
%A Pascual, María Jesús
%A Hernández Boluda, Juan Carlos
%A Gago, Beatriz
%A Vázquez, Lourdes
%A Piñana, José Luis
%A García, Magdalena
%A Pérez, Ariadna
%A Serrano, David
%A Hernández Martín, Marta María
%A Albert, Eliseo
%A Solano, Carlos
%A Navarro, David
%T Incidence, features, and outcomes of cytomegalovirus DNAemia in unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with post‐transplantation cyclophosphamide
%D 2019
%@ 1398-2273
%@ 1399-3062
%U https://hdl.handle.net/20.500.14352/108183
%X Background: Conflicting data have been published as to the risk of cytomegalovirus (CMV) DNAemia and CMV disease in patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with post-transplantationcyclophosphamide.Methods: We conducted a multicenter retrospective study including 118 patients subjected to unmanipulated haplo-HSCT to further clarify this issue. An historic cohort comprising 165 patients undergoing other transplant modalities (HLA-matched related, matched unrelated or mismatched) was built for comparison purposes. Plasma CMV DNA monitoring was performed using two highly sensitive real-time PCR assays.Results: Overall, the cumulative incidence of CMV DNAemia, recurrent CMV DNAemia, and CMV DNAemia requiring preemptive antiviral therapy in patients undergoinghaplo-HSCT was 63.9%, 34.9%, and 50.1%, respectively. These figures were rathercomparable for other transplant modalities (P = .22, P = .13 and P = .72, respectively).A trend toward longer duration of episodes and shorter CMV DNA doubling timeswas observed in haplo-HSCT patients in comparison with other transplant modalities.Furthermore, median CMV DNA peak load was significantly higher in haplo-HSCTs(P = .008), yet overall mortality by day 180 and 365 was the same across comparisongroups. There were five cases of CMV disease, and all occurred in haplo-HSCT patients.This latter observation is worrying and merits further investigation.Conclusions: The incidence of initial and recurrent episodes of CMV DNAemia eitherrequiring or not antiviral therapy in unmanipulated haplo-HSCT was comparable toother transplant modalities in our cohort.
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