%0 Journal Article
%A Quintana Villamandos, María Begoña
%A Arnalich Montiel, Ana
%A Arribas, Silvia
%A Lüneburg, Nicole
%A Böger, Rainer
%A Delgado Martos, María Jesús
%A Fernández Criado, Carmen
%A Delgado Baeza, Emilio
%A González, María del Carmen
%T Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats
%D 2016
%@ 0916-9636
%U https://hdl.handle.net/20.500.14352/98662
%X Our preclinical study demonstrated that esmolol produces early regression of left ventricular hypertrophy in arterial hypertension.The aim of this study was to assess the effects of short-term esmolol therapy on the regression of left anterior descending arteryremodeling in spontaneously hypertensive rats (SHRs), and to determine whether the asymmetric dimethylarginine (ADMA)/dimethylarginine dimethylaminohydrolase (DDAH) pathway, a regulator of nitric oxide (NO) bioavailability, accounted for thisregression. Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR,n=15) or esmolol (SHR-E,n=20)(300μgkg−1min−1). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY,n=15) served as controls. SHRs were alsotreated with nitroglycerin (SHR-N,n=5). After 48 h, the left anterior descending artery structure and morphology were assessed,and dose–response curves for 5-hydroxytryptamine (5-HT, 10−9–3×10−5mol l−1) were constructed. ADMA concentrations inplasma and left ventricle and DDAH activity in tissue were analyzed. Wall thickness and cross-sectional area were significantlylower after treatment with esmolol in SHR-E than in SHR. Media thickness and smooth muscle cell count were lower in SHR-Ethan in SHR. Esmolol induced a significant reduction in adventitial cell count in SHR-E. The area under the concentration–response curves was significantly higher in SHR than in SHR-E, as were the esmolol normalized coronary artery contractingresponses to 5-HT. We found significantly lower ADMA levels and significantly higher DDAH activity in the ventricle in SHR-Ethan in SHR. The protective effect of esmolol on the regression of left anterior descending artery remodeling may be related tothe reduction in ADMA levels.
%~