RT Journal Article
T1 Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats
A1 Quintana Villamandos, María Begoña
A1 Arnalich Montiel, Ana
A1 Arribas, Silvia
A1 Lüneburg, Nicole
A1 Böger, Rainer
A1 Delgado Martos, María Jesús
A1 Fernández Criado, Carmen
A1 Delgado Baeza, Emilio
A1 González, María del Carmen
AB Our preclinical study demonstrated that esmolol produces early regression of left ventricular hypertrophy in arterial hypertension.The aim of this study was to assess the effects of short-term esmolol therapy on the regression of left anterior descending arteryremodeling in spontaneously hypertensive rats (SHRs), and to determine whether the asymmetric dimethylarginine (ADMA)/dimethylarginine dimethylaminohydrolase (DDAH) pathway, a regulator of nitric oxide (NO) bioavailability, accounted for thisregression. Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR,n=15) or esmolol (SHR-E,n=20)(300μgkg−1min−1). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY,n=15) served as controls. SHRs were alsotreated with nitroglycerin (SHR-N,n=5). After 48 h, the left anterior descending artery structure and morphology were assessed,and dose–response curves for 5-hydroxytryptamine (5-HT, 10−9–3×10−5mol l−1) were constructed. ADMA concentrations inplasma and left ventricle and DDAH activity in tissue were analyzed. Wall thickness and cross-sectional area were significantlylower after treatment with esmolol in SHR-E than in SHR. Media thickness and smooth muscle cell count were lower in SHR-Ethan in SHR. Esmolol induced a significant reduction in adventitial cell count in SHR-E. The area under the concentration–response curves was significantly higher in SHR than in SHR-E, as were the esmolol normalized coronary artery contractingresponses to 5-HT. We found significantly lower ADMA levels and significantly higher DDAH activity in the ventricle in SHR-Ethan in SHR. The protective effect of esmolol on the regression of left anterior descending artery remodeling may be related tothe reduction in ADMA levels.
PB Springer Nature
SN 0916-9636
YR 2016
FD 2016-06-02
LK https://hdl.handle.net/20.500.14352/98662
UL https://hdl.handle.net/20.500.14352/98662
LA eng
DS Docta Complutense
RD 21 abr 2025