RT Journal Article
T1 Transcriptional regulation of the Salmonella enterica std fimbrial operon by the RcsCDB system
A1 Farizano, Juan V.
A1 García Pastor, Lucía
A1 Casadesús, Josep
A1 Delgado, Mónica
AB In Salmonella enterica serovar Typhimurium, the RcsCDB regulatory system controls the expression of genes involved in synthesis of colanic acid, formation of flagella and virulence. Here, we show that activation of the RcsCDB system downregulates expression of std, an operon that encodes fimbriae involved in Salmonella attachment to the mucus layer in the large intestine. Bioinformatic analysis predicts the existence of an RcsB-binding site located 180 bp upstream to the +1 transcription start site of the std promoter, and electrophoretic mobility shift assays confirm that RcsB binds the std promoter region in vitro. This study adds RcsB to the list of regulators of std transcription and provides an example of modulation of fimbriae synthesis by a signal transduction system.
SN 1350-0872
YR 2019
FD 2019-09-05
LK https://hdl.handle.net/20.500.14352/98818
UL https://hdl.handle.net/20.500.14352/98818
LA eng
NO Consejo Nacional de Investigaciones Científicas y Tecnológicas
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Regional Fund
NO Agencia Nacional de Promoción Científica y Tecnológica
NO Consejo de Investigaciones de la Universidad Nacional de Tucumán
DS Docta Complutense
RD 5 abr 2025