RT Journal Article
T1 Characterization of Fetal Brain Damage in Early Abortions of Ovine Toxoplasmosis
A1 Gutierrez Expósito, Daniel
A1 Arteche Villasol, Noive
A1 Vallejo García, Raquel
A1 Ferreras Estrada, Maria del Carmen
A1 Ferré Pérez, Ignacio
A1 Sánchez Sánchez, Roberto
A1 Ortega Mora, Luis Miguel
A1 Pérez, Valentín
A1 Benavides, Julio
AB There is an unacknowledged clinical presentation of ovine toxoplasmosis characterized by early abortions and lesions of fetal leukoencephalomalacia. To investigate the pathogenesis of this condition, the extent and distribution of leukomalacia and the variations in the cell populations associated with it were characterized in 32 fetal brains from 2 previously published experimental studies of Toxoplasma gondii infection in pregnant sheep. Immunohistochemical labeling of βAPP allowed for the detection of leukomalacia in 100/110 (91%) studied samples. There was no clear influence of the challenge dose or the area of the brain (frontal lobe, corpus callosum, midbrain, and cerebellum). In tissues with leukomalacia, there was loss of oligodendrocytes and increased number of astrocytes and microglia both in the areas of necrosis but also in the surrounding area. These findings were similar to those described in ovine experimental models (inflammation syndrome and hypoxic models) of periventricular leukomalacia in humans. Thus, a fetal inflammatory syndrome may be involved in the pathogenesis of early abortion in ovine toxoplasmosis. However, further studies are needed to determine the pathogenesis of this clinical presentation because placental thrombosis and resulting hypoxia could also be responsible for the leukomalacia.
PB Sage Publications
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/112015
UL https://hdl.handle.net/20.500.14352/112015
LA eng
NO Gutiérrez-Expósito, D., Arteche-Villasol, N., Vallejo-García, R., Ferreras-Estrada, M. C., Ferre, I., Sánchez-Sánchez, R., Ortega-Mora, L. M., Pérez, V., & Benavides, J. (2020). Characterization of Fetal Brain Damage in Early Abortions of Ovine Toxoplasmosis. Veterinary pathology, 57(4), 535–544. https://doi.org/10.1177/0300985820921539
NO Junta de Castilla y León
NO Ministerio de Ciencia e Innovación (España)
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 9 abr 2025