RT Journal Article
T1 Concerted regulation of non-alcoholic fatty liver disease progression by microRNAs in apolipoprotein E-deficient mice
A1 López-Pastor, Andrea R.
A1 Infante-Menéndez, Jorge
A1 González-Illanes, Tamara
A1 González-López, Paula
A1 González-Rodríguez, Águeda
A1 García-Monzón, Carmelo
A1 Vega de Céniga, Melina
A1 Esparza, Leticia
A1 Gómez Hernández, María De La Almudena
A1 Escribano Illanes, Óscar
AB The prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing, and altered expression of microRNAs (miRNAs) fosters the development and progression of many pathologies, including NAFLD. Therefore, we explored the role of new miRNAs involved in the molecular mechanisms that trigger NAFLD progression and evaluated them as biomarkers for diagnosis. As a NAFLD model, we used apolipoprotein E-deficient mice administered a high-fat diet for 8 or 18 weeks. We demonstrated that insulin resistance and decreased lipogenesis and autophagy observed after 18 weeks on the diet are related to a concerted regulation carried out by miR-26b-5p, miR-34a-5p, miR-149-5p and miR-375-3p. We also propose circulating let-7d-5p and miR-146b-5p as potential biomarkers of early stages of NAFLD. Finally, we confirmed that circulating miR-34a-5p and miR-375-3p are elevated in the late stages of NAFLD and that miR-27b-3p and miR-122-5p are increased with disease progression. Our results reveal a synergistic regulation of key processes in NAFLD development and progression by miRNAs. Further investigation is needed to unravel the roles of these miRNAs for developing new strategies for NAFLD treatment.
PB The Company of Biologists
SN 1754-8403
YR 2021
FD 2021-12
LK https://hdl.handle.net/20.500.14352/93715
UL https://hdl.handle.net/20.500.14352/93715
LA eng
NO López-Pastor AR, Infante-Menéndez J, González-Illanes T, González-López P, González-Rodríguez Á, García-Monzón C, et al. Concerted regulation of non-alcoholic fatty liver disease progression by microRNAs in apolipoprotein E-deficient mice. Disease Models & Mechanisms 2021;14:dmm049173. https://doi.org/10.1242/dmm.049173.
NO Ministerio de Ciencia, Innovación y Universidades
NO Banco Santander
NO Universidad Complutense de Madrid
NO Consejería de Ciencia, Universidades e Innovación de la Comunidad de Madrid
NO European Social Fund
DS Docta Complutense
RD 24 abr 2025