RT Journal Article
T1 Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers
A1 Paris, J.L.
A1 Cabañas Criado, María Victoria
A1 Manzano García, Miguel
A1 Vallet Regí, María Dulce Nombre
AB A new ultrasound-responsive system based on mesoporous silica nanoparticles was developed for biomedical applications, grafting a copolymer on their surface that acts as gatekeeper of the pores. The nanoparticles can be loaded with a cargo at low temperature (4 degrees C), taking advantage of the open conformation that the polymer presents under these conditions. Then, at 37 degrees C the copolymer collapses closing the pore entrances and allowing the nanoparticles to carry the drugs at physiological temperature without premature release, which is of great importance when dealing with cytotoxic drugs in cancer treatments. Upon ultrasound irradiation, the sensitive polymer changes its hydrophobicity and, therefore, its conformation toward coil-like opening the gates and releasing the cargo. These hybrid nanoparticles have been shown to be noncytotoxic and can be internalized into LNCaP cells retaining their ultrasound-responsive capability in the cytoplasm of the cells. Moreover, doxorubicin-loaded hybrid MSNs were incubated with LNCaP cells to show their capacity to induce cell death only when the nanoparticles had been exposed to ultrasound. This work demonstrates that our hybrid-MSNs can be triggered by remote stimuli, which is of capital importance for future applications in drug delivery and cancer therapy.
PB American Chemical Society
SN 1936-0851
YR 2015
FD 2015-09-11
LK https://hdl.handle.net/20.500.14352/23183
UL https://hdl.handle.net/20.500.14352/23183
LA eng
NO RESEARCHER ID K-3719-2014 (Miguel Manzano García)ORCID 0000-0001-6238-6111 (Miguel Manzano García)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)
NO Ministerio de Economía y Competitividad (MINECO)
NO CIBER-BBN
NO VI National RDi Plan
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 21 abr 2025