RT Journal Article
T1 An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines
A1 Pérez-López, Alexandre
A1 Torres Suárez, Ana Isabel
A1 Martín Sabroso, Cristina
A1 Aparicio Blanco, Juan
AB The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system. As a result, brain diseases remain one of the greatest unmet medical needs. Understanding the tridimensional structure of the BBB helps gain insight into the pathology of the BBB and contributes to the development of novel therapies for brain diseases. Therefore, 3D models with an ever-growing sophisticated complexity are being developed to closely mimic the human neurovascular unit. Among these 3D models, hydrogel-, spheroid- and organoid-based static BBB models have been developed, and so have microfluidic-based BBB-on-a-chip models. The different 3D preclinical models of the BBB, both in health and disease, are here reviewed, from their development to their application for permeability testing of nanomedicines across the BBB, discussing the advantages and disadvantages of each model. The validation with data from in vivo preclinical data is also discussed in those cases where provided.
PB Elsevier
SN 0169-409X
YR 2023
FD 2023-03-30
LK https://hdl.handle.net/20.500.14352/112045
UL https://hdl.handle.net/20.500.14352/112045
LA eng
NO Alexandre Pérez-López, Ana Isabel Torres-Suárez, Cristina Martín-Sabroso, Juan Aparicio-Blanco, An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines, Advanced Drug Delivery Reviews, Volume 196, 2023, 114816, https://doi.org/10.1016/j.addr.2023.114816.
NO 2024 Acuerdos transformativos CRUE
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 4 abr 2025