%0 Journal Article
%A Quignodon, Laure
%A Grijota Martínez, María Carmen
%A Compe, Emmanuel
%A Guyot, Romain
%A Allioli, Nathalie
%A Laperriere, David
%A Walker, Robert
%A Meltzer, Paul
%A Mader, Sylvie
%A Samarut, Jacques
%A Flamant, Frédéric
%T A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum
%D 2007
%@ 0952-5041
%U https://hdl.handle.net/20.500.14352/92094
%X Thyroid hormones act directly on gene transcription in the post-natal developing cerebellum, controlling neuronal, and glial cell differentiation. We have combined three experimental approaches to identify the target genes that are underlying this phenomenon: 1) a microarray analysis of gene expression to identify hormone responsive genes in the cerebellum of Pax8-/- mice, a transgenic mouse model of congenital hypothyroidism; 2) a similar microarray analysis on primary culture of cerebellum neurons; and 3) a bioinformatics screen of conserved putative-binding sites in the mouse genome. This identifies surprisingly a small set of target genes, which, for some of them, might be key regulators of cerebellum development and neuronal differentiation.
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