RT Journal Article
T1 A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum
A1 Quignodon, Laure
A1 Grijota Martínez, María Carmen
A1 Compe, Emmanuel
A1 Guyot, Romain
A1 Allioli, Nathalie
A1 Laperriere, David
A1 Walker, Robert
A1 Meltzer, Paul
A1 Mader, Sylvie
A1 Samarut, Jacques
A1 Flamant, Frédéric
AB Thyroid hormones act directly on gene transcription in the post-natal developing cerebellum, controlling neuronal, and glial cell differentiation. We have combined three experimental approaches to identify the target genes that are underlying this phenomenon: 1) a microarray analysis of gene expression to identify hormone responsive genes in the cerebellum of Pax8-/- mice, a transgenic mouse model of congenital hypothyroidism; 2) a similar microarray analysis on primary culture of cerebellum neurons; and 3) a bioinformatics screen of conserved putative-binding sites in the mouse genome. This identifies surprisingly a small set of target genes, which, for some of them, might be key regulators of cerebellum development and neuronal differentiation.
PB BioScientifica
SN 0952-5041
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/92094
UL https://hdl.handle.net/20.500.14352/92094
LA eng
NO Quignodon, L., et al. «A Combined Approach Identifies a Limited Number of New Thyroid Hormone Target Genes in Post-Natal Mouse Cerebellum». Journal of Molecular Endocrinology, vol. 39, n.o 1, julio de 2007, pp. 17-28. DOI.org (Crossref), https://doi.org/10.1677/JME-06-0054.
NO Ministry of Research (France)
NO League against Cancer (Francia)
NO European Commission
NO Association for Cancer Research (France)
NO Foundation for Medical Research (France)
DS Docta Complutense
RD 29 abr 2025