RT Journal Article
T1 Impact of selenium co-administration on methyl mercury exposed eleutheroembryos and adult zebrafish (Danio rerio): changes in bioaccumulation and gene expression
A1 Sanz Landaluce, Jon
A1 Cabezas Sánchez, Pablo
A1 Rainieri, Sandra
A1 Conlledo, Nadia
A1 Cámara Rica, Carmen
A1 Luque García, José Luis
AB Mercury still represents one of the most hazardous threats for the aquatic ecosystem due to its high toxicity, and the fact that it can be easily incorporated into the food chain by accumulation in fish as MeHg. On the other hand, selenium is a micronutrient that is part of different antioxidant enzymes that regulate the cellular redox state, and whose complex interaction with Hg has been extensively studied from a toxicological point of view. In order to evaluate the protective effect of Se(IV) co-administration against MeHg accumulation and toxicity, we have selected an in-vivo model at two developmental stages: zebrafish eleutheroembryos and adult fish. Embryos were exposed during 48 h to MeHg (5 or25 mg/l) and a concentration of Se (IV) representing a molar ratio close to one (2.5 or 12.5 mg/l), while adult zebrafish were exposed during 72 h to either 25 mg/l of MeHg alone or co-exposed with 12.5 mg/l of Se (IV). A significant decrease in MeHg bioaccumulation factor was observed in eleutheroembryos coexposed to Se(IV). A time-dependent accumulation of MeHg was observed in all the analyzed organs and tissues of adult fish, which was significantly reduced in the muscular tissue and the intestine by Se(IV) co-administration. However, such protection against MeHg bioaccumulation was not maintained in the brain and liver. The data derived from the gene expression analysis also demonstrated the protective effect of Se(IV) against MeHg-induced oxidative stress and the activation of different defense mechanisms by Se(IV) co-administration.
PB Elsevier
YR 2019
FD 2019-07-10
LK https://hdl.handle.net/20.500.14352/113562
UL https://hdl.handle.net/20.500.14352/113562
LA eng
NO Pablo Cabezas-Sanchez, Sandra Rainieri, Nadia Conlledo, Alejandro Barranco, Jon Sanz-Landaluze, Carmen Camara, Jose L. Luque-Garcia, Impact of selenium co-administration on methylmercury exposed eleutheroembryos and adult zebrafish (Danio rerio): Changes in bioaccumulation and gene expression, Chemosphere, Volume 236, 2019, 124295, ISSN 0045-6535
DS Docta Complutense
RD 10 abr 2025