RT Journal Article
T1 Towards a unified mechanistic theory of aging
A1 Barja de Quiroga, Gustavo
AB A large amount of the longevity-modulating genes discovered during the last two decades are highly conserved during evolution from yeast and invertebrates to mammals. Many different kinds of evidence converge in the concept that life extending manipulations like the dietary restrictions or rapamycin signal the nucleus specifically changing gene expression to increase longevity. The response of the cell aging regulation system is to change the level of activity of many different aging effectors to modulate longevity. Aging effectors include mitROS production, lipid unsaturation, autophagy, mitochondrial DNA repair and possibly others like apoptosis, proteostasis, or telomere shortening, corresponding to different classic theories of aging. The constitutive spontaneous activity of this aging regulating system, likely including epigenetics, can also explain species longevity. The aging regulating system reconciles the previously considered independent theories of aging bringing them together into a single unified theory of aging.
PB Elsevier
SN 0531-5565, ESSN: 1873-6815
YR 2019
FD 2019-09
LK https://hdl.handle.net/20.500.14352/13820
UL https://hdl.handle.net/20.500.14352/13820
LA eng
NO Unión Europea
NO Ministerio de Ciencia, Innovación y Universidades
NO FISss
NO UCM
DS Docta Complutense
RD 3 may 2024