RT Journal Article
T1 Perinatal free‐choice of a high‐calorie low‐protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood
A1 Rivera, Patricia
A1 Ramírez López, María Teresa
A1 Vargas, Antonio
A1 Decara, Juan
A1 Vázquez, Mariam
A1 Arco, Rocío
A1 Gómez De Heras, María Raquel
A1 Argente, Jesús
A1 Rodríguez De Fonseca, Fernando Antonio
A1 Chowen, Julie A.
A1 Suárez, Juan
AB We aimed to investigate whether a dysregulated maternal diet during gestation and lactation induces long‐lasting changes in the hypothalamic control of feeding behavior in the offspring and whether this effect is sex specific. Methods: The study included an analysis of appetite‐regulating metabolic hormones and hypothalamic signaling in male and female offspring in adulthood after exposure to a free‐choice high‐calorie palatable low‐protein (P) diet or standard chow (C) during (pre)gestation/lactation (maternal) and/or postweaning (offspring).Results: Maternal exposure to the P diet resulted in decreased protein intake and body weight gain in dams and decreased body weight gain in offspring during lactation. The maternal P diet (PC) specifically increased feed efficacy and decreased body weight and cholesterol levels in the female offspring in adulthood, but no changes in adiposity or leptin levels were found. In contrast, P diet exposure after weaning (CP and PP) increased caloric intake, adiposity and circulating levels of leptin in the male and female offspring in adulthood. The hypothalami of the female offspring exposed to the maternal P diet (PC and PP) expressed high levels of the phospho‐leptin receptor and low levels of SOCS3, phospho‐IRS1 and phospho‐AMPK, regardless of the postweaning diet. The hypothalami of the female rats in the PC group also showed increased levels of STAT3 and the orexigenic neuropeptide.Conclusions : Maternal exposure to a free‐choice high‐calorie low‐protein diet induces a long‐term feed efficacy associated with changes in leptin signaling through IRS‐1 and AMPK dephosphorylation in the hypothalami of female offspring in adulthood.
PB Wiley
SN 1748-1708
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/101305
UL https://hdl.handle.net/20.500.14352/101305
LA eng
NO Rivera, Patricia, et al. «Perinatal Free‐choice of a High‐calorie Low‐protein Diet Affects Leptin Signaling through IRS1 and AMPK Dephosphorylation in the Hypothalami of Female Rat Offspring in Adulthood». Acta Physiologica, vol. 226, n.o 2, junio de 2019, p. e13244. https://doi.org/10.1111/apha.13244.
NO Junta de Andalucía
NO European Commission
NO Ministerio de Economía y Competitividad (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 21 abr 2025