RT Journal Article T1 Detection of Histamine Dihydrochloride at Low Concentrations Using Raman Spectroscopy Enhanced by Gold Nanostars Colloids A1 Kolosovas Machuca, Eleazar Samuel A1 Cuadrado Conde, Alexander A1 Ojeda Galván, Hiram Joazet A1 Ortiz Dosal, Luis Carlos A1 Hernández Arteaga, Aida Catalina A1 Rodríguez Aranda, María del Carmen A1 Navarro Contreras, Hugo Ricardo A1 Alda, Javier A1 González Contreras, Francisco Javier AB In this paper, we report a fast and easy method to detect histamine dihydrochloride using gold nanostars in colloidal aqueous solution as a highly active SERS platform with potential applications in biomedicine and food science. This colloid was characterized with SEM and UV–Vis spectroscopy. Also, numerical calculations were performed to estimate the plasmonic resonance and electric field amplification of the gold nanoparticles to compare the difference between nanospheres and nanostars. Finally, aqueous solutions of histamine dihydrochloride were prepared in a wide range of concentrations and the colloid was added to carry out SERS. We found SERS amplified the Raman signal of histamine by an enhancement factor of 1.0 × 10 7 , demonstrating the capability of the method to detect low concentrations of this amine molecule. PB MDPI SN 2079-4991 YR 2019 FD 2019-02-06 LK https://hdl.handle.net/20.500.14352/13106 UL https://hdl.handle.net/20.500.14352/13106 LA eng NO Received: 20 December 2018 / Revised: 16 January 2019 / Accepted: 22 January 2019 / Published: 6 February 2019(This article belongs to the Special Issue Biomedical Applications of Nanoparticles) NO Consejo Nacional de Ciencia y Tecnología (CONACyT) (México) NO Terahertz Science and Technology National Lab (LANCYTT) NO Universidad Autónoma San Luis de Potosí (México) DS Docta Complutense RD 9 abr 2025