RT Journal Article
T1 Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
A1 Biezma, María
A1 Muñoz, Patricia
A1 Villa, Sofía de la
A1 Fariñas-Álvarez, María del Carmen
A1 Arnáiz de las Revillas, Francisco
A1 Gutiérrez Carretero, Encarnación
A1 Alarcón, Arístides de
A1 Rodríguez García, Raquel
A1 Llopis, Jaume
A1 Goenaga, Miguel
A1 Gutiérrez Villanueva, Andrea
A1 Plata, Antonio
A1 Vidal, Laura
A1 Martínez-Sellés D Oliveira Soares, Manuel
AB Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.
PB MPDI
SN 2077-0383
YR 2022
FD 2022-05-09
LK https://hdl.handle.net/20.500.14352/71723
UL https://hdl.handle.net/20.500.14352/71723
LA eng
DS Docta Complutense
RD 12 abr 2025