RT Journal Article
T1 Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization
A1 Delpón Mosquera, María Eva
A1 Caballero Collado, Ricardo
A1 Gómez García, Ricardo
A1 Núñez Fernández, Lucía
A1 Tamargo Menéndez, Juan
AB Angiotensin II and aldosterone produce pro-arrhythmic effects by several mechanisms, including the modulation of voltage-dependent K(+) channels involved in human cardiac repolarization. Drugs that inhibit the renin-angiotensin-aldosterone system exert anti-arrhythmic actions that are related to the blockade of the pro-arrhythmic actions of angiotensin II and aldosterone. These anti-arrhythmic actions include inhibition of electrical and structural cardiac remodeling, inhibition of neurohumoral activation, reduction of blood pressure and stabilization of electrolyte disturbances. In this article, several angiotensin II AT(1) receptor antagonists (candesartan, E3174, eprosartan, irbesartan and losartan) and aldosterone receptor antagonists (canrenoic acid and spironolactone) that directly modulate the activity of the voltage-dependent K(+) channels are reviewed; the effects of these antagonists might be useful in the prevention and treatment of cardiac arrhythmias.
PB Cell Press
SN 0165-6147
YR 2005
FD 2005-03-01
LK https://hdl.handle.net/20.500.14352/100155
UL https://hdl.handle.net/20.500.14352/100155
LA eng
NO Delpón E, Caballero R, Gómez R, Núñez L, Tamargo J. Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization. Trends Pharmacol Sci. 2005 Mar;26(3):155-61. doi: 10.1016/j.tips.2005.01.006
NO Comisión Interministerial de Ciencia y Tecnología
NO Red Temática de Investigación Cardiovascular
NO Pfizer Foundation
DS Docta Complutense
RD 8 abr 2025