RT Journal Article
T1 Hybrid functionalized coatings on Metallic Biomaterials for Tissue Engineering
A1 Santos Coquillat, Ana María
A1 Martínez Campos, Enrique
A1 Mora Sánchez, Hugo
A1 Moreno Turiegano, Lara
A1 Arrabal Durán, Raúl
A1 Mohedano Sánchez, Marta
A1 Gallardo, Alberto
A1 Rodríguez Hernández, Juan
A1 Matykina, Endzhe
AB The review encompasses state-of-the-art strategies for design and fabrication of smart biomaterials for tissue engineering. The focus of the work is mainly put on metallic biomaterials with hybrid coatings consisting of bioceramic and polymeric layers with hierarchical organization and drug-eluting capacity.Key technologies and steps to design hybrid smart and multifunctional coatings on metallic cores for bone regeneration implants and cardiovascular stents are outlined, including additive manufacturing of titanium and magnesium alloys for permanent and temporary implant applications. Three levels of hierarchical surface functionalization are described: i) in situ modification of the core material, incorporating bioactive inorganic species and phases by means of ceramic coatings via anodic electrochemical treatments; ii) post-treatment application of polymer layers, monolithic or with specific porous breath figure topography; and iii) application of a cellular therapy component (single cell or cell sheet). Recent progress in incorporation of drug-eluting functionality into such materials via direct or nanocarrier-assisted loading is also highlighted.
PB Elsevier
SN 0257-8972
YR 2021
FD 2021-07-17
LK https://hdl.handle.net/20.500.14352/4756
UL https://hdl.handle.net/20.500.14352/4756
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)/FEDER
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III (ISCIII)
DS Docta Complutense
RD 18 abr 2025