RT Journal Article
T1 Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
A1 Salinero Fort, Miguel Ángel
A1 San Andrés Rebollo, Francisco Javier
A1 Cárdenas Valladolid, Juan
A1 Méndez Bailón, Manuel
A1 Chico Moraleja, R. M.
A1 Carrillo de Santa Pau, Enrique
A1 Jiménez Trujillo, María Isabel
A1 Gómez Campelo, I.
A1 De Burgos Lunar, Carmen
A1 Miguel Yanes, José María De
A1 MADIABETES, 
AB We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90-1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65-85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88-6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).
PB Nature Research
YR 2021
FD 2021-07-27
LK https://hdl.handle.net/20.500.14352/92802
UL https://hdl.handle.net/20.500.14352/92802
LA eng
NO Salinero-Fort MA, Andrés-Rebollo FJS, Cárdenas-Valladolid J, Méndez-Bailón M, Chico-Moraleja RM, de Santa Pau EC, Jiménez-Trujillo I, Gómez-Campelo I, de Burgos Lunar C, de Miguel-Yanes JM; MADIABETES. Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort. Sci Rep. 2021 Jul 27;11(1):15245. Erratum in: Sci Rep. 2022 Apr 8;12(1):5945
NO Instituto de Salud Carlos III
NO Unión Europea
DS Docta Complutense
RD 17 abr 2025