RT Journal Article T1 Craniofacial and three-dimensional palatal analysis in cleft lip and palate patients treated in Spain A1 Viñas Pinedo, María José A1 Galiotto Barba, Francesca A1 Berenguer, Beatriz A1 Lorca García, Concepción A1 Murillo González, Jorge Alfonso A1 Martínez Álvarez, María Concepción A1 Martínez Sanz, Elena AB Growth alterations have been described in patients operated on for oral clefts. The purpose of this work was to analyze the craniofacial and palate morphology and dimensions of young adults operated on for oral clefts in early childhood in Spain. Eighty-three patients from eight different hospitals were divided into four groups based on their type of cleft: cleft lip (CL, n = 6), unilateral cleft lip and palate (UCLP, n = 37), bilateral cleft lip and palate (BCLP, n = 16), and cleft palate only (CPO, n = 24). A control group was formed of 71 individuals. Three-dimensional (3D) digital models were obtained from all groups with an intraoral scanner, together with cephalometries and frontal, lateral, and submental facial photographs. Measurements were obtained and analyzed statistically. Our results showed craniofacial alterations in the BCLP, UCLP, and CPO groups with an influence on the palate, maxilla, and mandible and a direct impact on facial appearance. This effect was more severe in the BCLP group. Measurements in the CL group were similar to those in the control group. Cleft characteristics and cleft type seem to be the main determining factors of long-term craniofacial growth alterations in these patients. Prospective research is needed to clearly delineate the effects of different treatments on the craniofacial appearance of adult cleft patients. PB Springer Nature SN 2045-2322 YR 2022 FD 2022-11-06 LK https://hdl.handle.net/20.500.14352/102479 UL https://hdl.handle.net/20.500.14352/102479 LA eng NO Viñas MJ, Galiotto-Barba F, Cortez-Lede MG, Rodríguez-González MÁ, Moral I, Delso E, González-Meli B, Lobo F, López-Cedrún JL, Neagu D, Garatea J, Garatea A, Berenguer B, Lorca-García C, Delgado MD, Martí E, Gutiérrez JM, Hernández C, Murillo-González J, Martínez-Álvarez C, Martínez-Sanz E. Craniofacial and three-dimensional palatal analysis in cleft lip and palate patients treated in Spain. Sci Rep. 2022 Nov 6;12(1):18837. NO Ministerio de Ciencia e Innovación NO Instituto de Salud Carlos III NO Banco Santander NO Universidad Complutense de Madrid DS Docta Complutense RD 8 jun 2025