RT Journal Article
T1 Eudragit® L100/chitosan composite thin bilayer films for intravaginal pH-responsive release of Tenofovir
A1 Martín Illana, Araceli
A1 Cazorla Luna, Raúl
A1 Notario Pérez, Fernando
A1 Rubio, Juan
A1 Ruiz Caro, Roberto
A1 Tamayo, Aitana
A1 Veiga Ochoa, María Dolores
AB The high rate of HIV new infections and AIDS-related deaths each year make prevention tools still necessary today. Different dosage forms – including films – for vaginal administration of antiretroviral drugs have been developed for this purpose. Six batches of Tenofovir-loaded films were formulated based on Eudragit® L100 (EL100) and chitosan, containing triethyl citrate and glycerol. In all the cases films structured in two layers – the upper layer mainly attributed to EL100 and the lower layer to chitosan – were revealed by SEM. A higher content in EL100 and plasticizers improves the mechanical properties and control over drug release in the vaginal medium without affecting mucoadhesion. The EL100-based layer acts as a structuring agent that controls Tenofovir release for days in the vaginal medium while it occurs in a few hours in the presence of seminal fluid. Bilayer films with the highest tested content of EL100 and plasticizers would be the most suitable as vaginal microbicides as they are easier to administer due to their excellent mechanical properties and they offer more comfortable posology and enhanced protection against HIV during intercourse due to their pH-responsive release of Tenofovir.
PB Elsevier
SN 0378-5173
YR 2022
FD 2022-02-05
LK https://hdl.handle.net/20.500.14352/71530
UL https://hdl.handle.net/20.500.14352/71530
LA eng
NO Martín Illana, A., Cazorla Luna, R., Notario Pérez, F. et al. «Eudragit® L100/Chitosan Composite Thin Bilayer Films for Intravaginal pH-Responsive Release of Tenofovir». International Journal of Pharmaceutics, vol. 616, marzo de 2022, p. 121554. DOI.org (Crossref), https://doi.org/10.1016/j.ijpharm.2022.121554.
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Ministerio de Ciencia, Innovación y Universidades (España)/Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 6 abr 2025