RT Journal Article
T1 Cefditoren and Ceftriaxone Enhance Complement-Mediated Immunity in the Presence of Specific Antibodies against Antibiotic-Resistant Pneumococcal Strains
A1 Ramos-Sevillano, Elisa
A1 Rodríguez-Sosa, Cinthya
A1 Cafini, Fabio
A1 Giménez, María José
A1 Navarro, Ana
A1 Sevillano Fernández, David
A1 Alou Cervera, Luis
A1 García, Ernesto
A1 Aguilar, Lorenzo
A1 Yuste, José
A2 Bernard Beall, 
AB Background: Specific antibodies mediate humoral and cellular protection against invading pathogens such as Streptococcus pneumoniae by activating complement mediated immunity, promoting phagocytosis and stimulating bacterial clearance. The emergence of pneumococcal strains with high levels of antibiotic resistance is of great concern worldwide and a serious threat for public health.Methodology/principal findings: Flow cytometry was used to determine whether complement-mediated immunity against three antibiotic-resistant S. pneumoniae clinical isolates is enhanced in the presence of sub-inhibitory concentrations of cefditoren and ceftriaxone. The binding of acute phase proteins such as C-reactive protein and serum amyloid P component, and of complement component C1q, to pneumococci was enhanced in the presence of serum plus either of these antibiotics. Both antibiotics therefore trigger the activation of the classical complement pathway against S. pneumoniae. C3b deposition was also increased in the presence of specific anti-pneumococcal antibodies and sub-inhibitory concentrations of cefditoren and ceftriaxone confirming that the presence of these antibiotics enhances complement-mediated immunity to S. pneumoniae.Conclusions/significance: Using cefditoren and ceftriaxone to promote the binding of acute phase proteins and C1q to pneumococci, and to increase C3b deposition, when anti-pneumococcal antibodies are present, might help reduce the impact of antibiotic resistance in S. pneumoniae infections.
PB PLOS
SN 1932-6203
YR 2012
FD 2012-09-05
LK https://hdl.handle.net/20.500.14352/107046
UL https://hdl.handle.net/20.500.14352/107046
LA eng
NO Ramos-Sevillano E, Rodríguez-Sosa C, Cafini F, Giménez MJ, Navarro A, Sevillano D, Alou L, García E, Aguilar L, Yuste J. Cefditoren and ceftriaxone enhance complement-mediated immunity in the presence of specific antibodies against antibiotic-resistant pneumococcal strains. PLoS One. 2012;7(9):e44135.
NO Dirección General de Investigación Científica y Técnica
NO Instituto de Salud Carlos III
NO Tedec-Meiji Farma S. A
DS Docta Complutense
RD 5 abr 2025