RT Journal Article
T1 Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
A1 Hionides Gutiérrez, Alejandro
A1 Mazariegos, Marina S.
A1 Alemany, Susana
A1 Nevzorova, Yulia
A1 Cubero Palero, Francisco Javier
A1 Sanz García, Carlos
AB The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD.
PB Elsevier
SN 0925-4439
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/101373
UL https://hdl.handle.net/20.500.14352/101373
LA eng
NO Gutierrez AH, Mazariegos MS, Alemany S, Nevzorova YA, Cubero FJ, Sanz-García C. Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease. Biochim Biophys Acta Mol Basis Dis. 2023 Apr;1869(4):166660. doi: 10.1016/j.bbadis.2023.166660. Epub 2023 Feb 8. PMID: 36764206.
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovación (España)
NO European Commission
DS Docta Complutense
RD 17 dic 2025