RT Journal Article
T1 One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases
A1 Van Voorhis, Wesley C.
A1 Hulverson, Matthew A.
A1 Choi, Ryan
A1 Huang, Wenlin
A1 Arnold, Samuel L. M.
A1 Schaefer, Deborah A.
A1 Betzer, Dana P.
A1 Vidadala, Rama S.R.
A1 Lee, Sangun
A1 Whitman, Grant R.
A1 Barrett, Lynn K.
A1 Maly, Dustin J.
A1 Riggs, Michael W.
A1 Fan, Erkang
A1 Kennedy, Thomas J.
A1 Tzipori, Saul
A1 Doggett, J. Stone
A1 Winzer, Pablo
A1 Anghel, Nicoleta
A1 Imhof, Dennis
A1 Müller, Joachim
A1 Hemphill, Andrew
A1 Ferré Pérez, Ignacio
A1 Sánchez Sánchez, Roberto
A1 Ortega Mora, Luis Miguel
A1 Ojo, Kayode K
AB This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, as well as livestock only diseases such as neosporosis. We have demonstrated proof-of-concept for BKI therapy in livestock models of cryptosporidiosis (newborn calves infected with Cryptosporidium parvum), toxoplasmosis (pregnant sheep infected with Toxoplasma gondii), and neosporosis (pregnant sheep infected with Neospora caninum). We discuss the potential uses of BKIs for the treatment of diseases caused by apicomplexan parasites in animals and humans, and the improvements that need to be made to further develop BKIs.
PB Elsevier
SN 0304-4017
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/111255
UL https://hdl.handle.net/20.500.14352/111255
LA eng
NO Van Voorhis, W. C., Hulverson, M. A., Choi, R., Huang, W., Arnold, S. L. M., Schaefer, D. A., Betzer, D. P., Vidadala, R. S. R., Lee, S., Whitman, G. R., Barrett, L. K., Maly, D. J., Riggs, M. W., Fan, E., Kennedy, T. J., Tzipori, S., Doggett, J. S., Winzer, P., Anghel, N., Imhof, D., … Ojo, K. K. (2021). One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases. Veterinary parasitology, 289, 109336. https://doi.org/10.1016/j.vetpar.2020.109336
NO Wesley C. Van Voorhis: Conceptualization, Writing - original draft, Writing - review & editing. Matthew A. Hulverson: Writing - review & editing. Ryan Choi: Writing - review & editing. Wenlin Huang: Writing - review & editing. Samuel L.M. Arnold: Writing - review & editing. Deborah A. Schaefer: Writing - review & editing. Dana P. Betzer: Writing - review & editing. Rama S.R. Vidadala: Writing - review & editing. Sangun Lee: Writing - review & editing. Grant R. Whitman: Writing - review & editing. Lynn K. Barrett: Writing - review & editing. Dustin J. Maly: Writing - review & editing. Michael W. Riggs: Writing - review & editing. Erkang Fan: Writing - review & editing. Thomas J. Kennedy: Writing - review & editing. Saul Tzipori: Writing - review & editing. J. Stone Doggett: Writing - review & editing. Pablo Winzer: Writing - review & editing. Nicoleta Anghel: Writing - review & editing. Dennis Imhof: Writing - review & editing. Joachim Müller: Writing - review & editing. Andrew Hemphill: Writing - review & editing. Ignacio Ferre: Writing - review & editing. Roberto Sanchez-Sanchez: Writing - review & editing. Luis Miguel Ortega-Mora: Writing - review & editing. Kayode K. Ojo: Writing - review & editing.
NO National Institute of Allergy and Infectious Diseases
NO National Institutes of Health
NO Department of Agriculture (Estados Unidos)
NO Swiss National Science Foundation
NO Bill & Melinda Gates Foundation
NO Department of Veterans Affairs Biomedical Laboratory Research and Development
DS Docta Complutense
RD 6 abr 2025