%0 Journal Article
%A Lythell, Emily
%A Suardíaz Delrío, Reynier
%A Hinchliffe, Philip
%A Hanpaibool, Chonnikan
%A Visitsatthawong, Surawit
%A Oliveira, Sofia 
%A Lang, Eric 
%A Surawatanawong, Panida
%A Lee, Vannajan Sanghiran
%A Rungrotmongkol, Thanyada
%A Fey, Natalie
%A Spencer, James
%A Mulholland, Adrian 
%T Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes
%D 2020
%@ 1359-7345
%U https://hdl.handle.net/20.500.14352/92414
%X MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono- rather than multinuclear member of the alkaline phosphatase superfamily.
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