RT Journal Article
T1 Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes
A1 Lythell, Emily
A1 Suardíaz Delrío, Reynier
A1 Hinchliffe, Philip
A1 Hanpaibool, Chonnikan
A1 Visitsatthawong, Surawit
A1 Oliveira, Sofia
A1 Lang, Eric
A1 Surawatanawong, Panida
A1 Lee, Vannajan Sanghiran
A1 Rungrotmongkol, Thanyada
A1 Fey, Natalie
A1 Spencer, James
A1 Mulholland, Adrian
AB MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono- rather than multinuclear member of the alkaline phosphatase superfamily.
PB Royal Society of Chemistry
SN 1359-7345
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/92414
UL https://hdl.handle.net/20.500.14352/92414
LA eng
NO Lythell, Emily, et al. «Resistance to the “Last Resort” Antibiotic Colistin: A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes». Chemical Communications, vol. 56, n.o 50, 2020, pp. 6874-77.  https://doi.org/10.1039/D0CC02520H.
NO Mahidol University (Thailand)
NO University of Bristol
NO Thailand Research Fund
NO Medical Research Council
NO Universiti Malaya (Malaysia)
NO Research England 
NO Royal Society of Chemistry
DS Docta Complutense
RD 7 abr 2025