TY  - JOUR
AU  - Lythell, Emily
AU  - Suardíaz Delrío, Reynier
AU  - Hinchliffe, Philip
AU  - Hanpaibool, Chonnikan
AU  - Visitsatthawong, Surawit
AU  - Oliveira, Sofia 
AU  - Lang, Eric 
AU  - Surawatanawong, Panida
AU  - Lee, Vannajan Sanghiran
AU  - Rungrotmongkol, Thanyada
AU  - Fey, Natalie
AU  - Spencer, James
AU  - Mulholland, Adrian 
PY  - 2020
DO  - 10.1039/d0cc02520h
SN  - 1359-7345
UR  - https://hdl.handle.net/20.500.14352/92414
T2  - Chemical Communications
AB  - MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR...
LA  - eng
M2  - 6874
PB  - Royal Society of Chemistry
KW  - Alkaline Phosphatase
KW  - Anti-Bacterial Agents
KW  - Bacterial Proteins
KW  - Colistin
KW  - Drug Resistance
KW  - Bacterial
KW  - Ethanolamines
KW  - Lipid A
KW  - Molecular Dynamics Simulation
KW  - Zinc
TI  - Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes
TY  - journal article
VL  - 56
ER  -