RT Journal Article
T1 Cocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent (CSS)
A1 Cuadra Mendoza, Isaac Alfonso
A1 Cabañas Poveda, Albertina
A1 Rodríguez Cheda, José Antonio
A1 Türk, MIchael
A1 Pando García-Pumarino, Concepción
AB Co-crystals of 5-fluorouracil (5-Fu) and the coformers urea, thiourea and pyrazinamide (PZA) were attempted for the first time through the supercritical antisolvent (SAS) and the cocrystallization with supercritical solvent (CSS) techniques. SAS operational conditions were temperature (313 K), pressure (7.0–15.0 MPa) and 5-Fu concentration in methanol (5 and 2.5 mg/mL). Coformer concentration was always in the desired stoichiometric ratio. Co-crystals were characterized using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Pure 5-Fu-urea cocrystals were obtained via SAS at 313 K and 8.0 MPa using a 5 mg/mL 5-Fu solution. All other SAS conditions studied led to 5-Fu homocrystal impurities. For comparison purposes 5-Fu, urea and thiourea were also processed by SAS. CSS produced a mixture of co-crystals and homocrystals only when supercritical CO2 was modified with methanol. Advantages and disadvantages of the two supercritical cocrystallization techniques are discussed.
PB Elsevier
SN 0896-8446
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/93480
UL https://hdl.handle.net/20.500.14352/93480
LA eng
NO Isaac A. Cuadra, Albertina Cabañas, José A.R. Cheda, Michael Türk, Concepción Pando, Cocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent (CSS), The Journal of Supercritical Fluids, Volume 160, 2020, 104813
NO Ministerio de Economía y Competitividad (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 9 abr 2025