RT Journal Article
T1 Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas
A1 Garrido Ruiz, Patricia Alejandra
A1 Hernández Laín, Aurelio
A1 Tabernero, María Dolores
AB <jats:p>Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.23 chromosomal region was the most observed chromosomal alteration, followed by losses of chromosomes 14, 1, 6, and 19, polysomies of chromosomes 17, 1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be classified into two genetic subgroups with distinct clinicopathologic features characterized by the presence of (1) chromosomal losses only and (2) combined losses and gains of several chromosomes. The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes.</jats:p>
PB MDPI
SN 1422-0067
YR 2023
FD 2023-01-06
LK https://hdl.handle.net/20.500.14352/104927
UL https://hdl.handle.net/20.500.14352/104927
LA eng
NO Garrido Ruiz, P.A.; González-Tablas, M.; Pasco Peña, A.; Zelaya Huerta, M.V.; Ortiz, J.; Otero, Á.; Corchete, L.A.; Ludeña, M.D.; Caballero Martínez, M.C.; Córdoba Iturriagagoitia, A.; et al. Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas. Int. J. Mol. Sci. 2023, 24, 1116. https://doi.org/10.3390/ijms24021116
NO Junta de Castilla y León (España)
NO Instituto de Salud Carlos III
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 15 abr 2026