RT Journal Article
T1 Multivalent Glycosylated Nanostructures for Ebola Virus Infection
A1 Illescas Martínez, Beatriz María
A1 Rojo, Javier
A1 Delgado Vázquez, Rafael
A1 Martín León, Nazario
AB The infection of humans by lethal pathogens such as Ebola and other related viruses has not been properly addressed so far. In this context, a relevant question arises: what can chemistry do in the search for new strategies and approaches to solve this emergent problem? Although initially a variety of known chemical compounds – for other purposes – have been disappointingly tested against Ebola virus infection, more recently, specific molecules have been prepared. In this Perspective, we present a new approach directed to the design of efficient entry inhibitors to minimize the development of resistance by viral mutations. In particular, we focused on dendrimers as well as fullerene C60 – with a unique symmetrical and 3D globular structure – as biocompatible carbon platforms for the multivalent presentation of carbohydrates. The antiviral activity of these compounds in an Ebola pseudotyped infection model were in the low micromolar range for fullerenes with 12 and 36 mannoses. However, new tridecafullerenes – in which the central alkyne scaffold of [60]fullerene has been connected to 12 sugar-containing [60]fullerene units (total 120 mannoses)– exhibit an outstanding antiviral activity with IC50 in the subnanomolar range! The multivalent presentation of specific carbohydrates by using 3D fullerenes as controlled biocompatible carbon scaffolds represents a real advance being currently the most efficient molecules in vitro against Ebola virus infection. However, additional studies are needed to determine the optimized fullerene-based leads for practical applications.
PB ACS
SN 0002-7863
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/18416
UL https://hdl.handle.net/20.500.14352/18416
LA eng
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 21 abr 2025