RT Journal Article
T1 The metabolic landscape of cancer stem cells
A1 Dando, Ilaria
A1 Dalla Pozza, Elisa
A1 Biondani, Giulia
A1 Cordani, Marco
A1 Palmieri, Marta
A1 Donadelli, Massimo
AB Cancer stem cells (CSCs) are a sub-population of quiescent cells endowed with self-renewal properties that can sustain the malignant behavior of the tumor mass giving rise to more differentiated cancer cells. For this reason, the specific killing of CSCs represents one of the most important challenges of the modern molecular oncology. However, their particular resistance to traditional chemotherapy and radiotherapy imposes a thorough understanding of their biological and biochemical features. The metabolic peculiarities of CSCs may be a therapeutic and diagnostic opportunity in cancer research. In this review, we summarize the most significant discoveries on the metabolism of CSCs describing and critically analyzing the studies supporting either glycolysis or mitochondrial oxidative phosphorylation as a primary source of energy for CSCs.
PB Wiley
SN 1521-6543
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/97260
UL https://hdl.handle.net/20.500.14352/97260
LA eng
NO Dando, Ilaria, et al. «The Metabolic Landscape of Cancer Stem Cells». IUBMB Life, vol. 67, n.o 9, septiembre de 2015, pp. 687-93. https://doi.org/10.1002/iub.1426.
NO Ministry of Education, University and Research (Italy)
NO Italian Research Association against Cancer
DS Docta Complutense
RD 6 abr 2025