RT Journal Article
T1 Molecular and evolutionary characteristics of chicken parvovirus (ChPV) genomes detected in chickens with runting–stunting syndrome
A1 Chacón, Ruy D.
A1 Sánchez Llatas, Christian J.
A1 Da Costa, Antonio Charlys
A1 Valdeiglesias Ichillumpa, Stefhany
A1 Cea Callejo, Pablo
A1 Marín Sánchez, Obert
A1 Astolfi Ferreira, Claudete S.
A1 Santander Parra, Silvana
A1 Nuñez, Luis F. N.
A1 Piantino Ferreira, Antonio J.
AB Chicken Parvovirus (ChPV) belongs to the genus Aveparvovirus and is implicated in enteric diseases like runting–stunting syndrome (RSS) in poultry. In RSS, chicken health is affected by diarrhea, depression, and increased mortality, causing significant economic losses in the poultry industry. This study aimed to characterize the ChPV genomes detected in chickens with RSS through a metagenomic approach and compare the molecular and evolutionary characteristics within the Aveparvovirus galliform1 species. The intestinal content of broiler flocks affected with RSS was submitted to viral metagenomics. The assembled prevalent genomes were identified as ChPV after sequence and phylogenetic analysis, which consistently clustered separately from Turkey Parvovirus (TuPV). The strain USP-574-A presented signs of genomic recombination. The selective pressure analysis indicated that most of the coding genes in A. galliform1 are evolving under diversifying (negative) selection. Protein modeling of ChPV and TuPV viral capsids identified high conservancy over the VP2 region. The prediction of epitopes identified several co-localized antigenic peptides from ChPV and TuPV, especially for T-cell epitopes, highlighting the immunological significance of these sites. However, most of these peptides presented host-specific variability, obeying an adaptive scenario. The results of this study show the evolutionary path of ChPV and TuPV, which are influenced by diversifying events such as genomic recombination and selective pressure, as well as by adaptation processes, and their subsequent immunological impact.
PB MDPI
YR 2024
FD 2024-08
LK https://hdl.handle.net/20.500.14352/119868
UL https://hdl.handle.net/20.500.14352/119868
LA eng
NO Chacón RD, Sánchez-Llatas CJ, Da Costa AC, Valdeiglesias Ichillumpa S, Cea-Callejo P, Marín-Sánchez O, Astolfi-Ferreira CS, Santander-Parra S, Nuñez LFN, Piantino Ferreira AJ. Molecular and Evolutionary Characteristics of Chicken Parvovirus (ChPV) Genomes Detected in Chickens with Runting–Stunting Syndrome. Viruses 2024;16:1389. https://doi.org/10.3390/v16091389.
NO Funding:The Article Processing Charge (APC) was supported by Universidad de Las Américas, Quito (Ecuador). A.J.P.F. was supported by the Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico (CNPq) under grant 301084/2019-0.
NO Universidad de Las Américas (Ecuador)
NO Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico (Brasil)
DS Docta Complutense
RD 26 dic 2025