RT Journal Article
T1 Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS
A1 Calvo Sánchez, María I.
A1 Fernández Martos, Sandra
A1 Montoya Miñano, Juan José
A1 Espada, Jesús
AB The emerging variety of signalling roles for ROS in eukaryotic cells and tissues is currently a matter of intense research. Here we make use of ex vivo cultured single human hair follicles as an experimental model to demonstrate that a transient production of non-lethal endogenous ROS levels in these mini-organs promotes efficiently the entry into the growth phase (anagen). The stimulatory process implicates the specific activation of the hair follicle stem cell niche, encompassing the induction of stem cell differentiation markers (Ck15), overall cell proliferation and sustained growth of the tissue associated with expression of gen targets (Ccnd1) concomitant with the inhibition of Wnt signaling antagonists and repressors (Dkk1, Gsk3β) of Wnt signaling. As a whole, this observation indicates that, once activated, ROS signalling is an intrinsic mechanism regulating the hair follicle stem cell niche independently of any external signal.
PB Nature Research
YR 2019
FD 2019-03-14
LK https://hdl.handle.net/20.500.14352/114709
UL https://hdl.handle.net/20.500.14352/114709
LA eng
NO Calvo-Sánchez, M.I., Fernández-Martos, S., Montoya, J.J. et al. Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS. Sci Rep 9, 4509 (2019). https://doi.org/10.1038/s41598-019-39992-8
NO Ministerio de Economía y Competitividad (España)
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 5 abr 2025