RT Journal Article
T1 Micronization of Ciprofloxacin by the Supercritical Antisolvent (SAS) Technique
A1 Zahran, Fouad
A1 Marzal, Pablo
A1 Ruiz Saldaña, Helga Karina
A1 Pérez Velilla, Eduardo
A1 Calvo Garrido, María Lourdes
A1 Cabañas Poveda, Albertina
AB Ciprofloxacin  is a broad-spectrum antibiotic that is proposed for pulmonary administration. In this work micronization of ciprofloxacin was performed by the Supercritical Antisolvent Technique (SAS) using ciprofloxacin base (CIP) in ethanol/acetic acid and ciprofloxacin hydrochloride salt (CIP·HCl ) in methanol at 40-60 ºC and 100-150 bar. Yields ranged from 40-90 %. CIP precipitated incorporating acetate whilst CIP·HCl precipitated as the AH1 anhydrous form. CIP and CIP·HCl particles exhibited an acicular morphology (0.2-0.9 μm wide x 1-4 μm long). Micronization adding lactose, PVP K-10 and K 30 did not change the crystalline form but modified the precipitate morphology. CIP·HCl:lactose and CIP·HCl:PVP K-30 at a 4:1 drug:excipient mass ratio precipitated like flakes. CIP·HCl:PVP K-10 precipitated as submicron globular particles suitable for oral formulation. Increasing the PVP content, the morphology changed to sheets and flakes, which could be used for pulmonary administration. The antibacterial activity of the samples for Staphylococcus epidermidis was confirmed.
PB ELSEVIER
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/108991
UL https://hdl.handle.net/20.500.14352/108991
LA eng
NO Ministerio de Ciencia,Innovación y Universidades (España)
NO Comunidad Autónoma de Madrid
DS Docta Complutense
RD 25 abr 2025