RT Journal Article
T1 Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
A1 Matesanz Sancho, María Concepción
A1 Linares, Javier
A1 Lilue, Isabel
A1 Sánchez Salcedo, Sandra
A1 Feito Castellano, María José
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
A1 Portolés Pérez, María Teresa
AB In the present study, the effects of nanocrystalline hydroxyapatite (nano-HA) and nanocrystalline Si-substituted hydroxyapatite (nano-SiHA) on osteoclast differentiation and resorptive activity have been evaluated in vitro using osteoclast-like cells. The action of these materials on proinflammatory and reparative macrophage populations was also studied. Nano-SiHA disks delayed the osteoclast differentiation and decreased the resorptive activity of these cells on their surface, as compared to nano-HA samples, without affecting cell viability. Powdered nano-SiHA also induced an increase of the reparative macrophage population. These results along with the beneficial effects on osteoblasts previously observed with powdered nano-SiHA suggest the potential of this biomaterial for modulating the fundamental processes of bone formation and turnover, preventing bone resorption and enhancing bone formation at implantation sites in treatment of osteoporotic bone and in bone repair and regeneration.
PB Royal Society of Chemistry
SN 2050-750X
YR 2014
FD 2014-05-21
LK https://hdl.handle.net/20.500.14352/35368
UL https://hdl.handle.net/20.500.14352/35368
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID N-4501-2014  (Sandra Sánchez Salcedo)ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovacion (MICINN)
NO Agening Network of Excellence
DS Docta Complutense
RD 12 abr 2025