RT Journal Article
T1 Neuroprotective effect of a ginseng (Panax ginseng) root extract on astrocytes primary culture
A1 Naval López, María Victoria
A1 Gómez-Serranillos Cuadrado, María Pilar
A1 Carretero Accame, María Emilia
A1 Villar Del Fresno, Ángel
AB A standardized aqueous extract of Panax ginseng radix was tested for its antioxidant effect on primary astrocytes culture on an oxidant stress model generated by H2O2. The results indicated that this extract had a significant effect on the reduction of astrocytic death induced by H2O2. Dose–response experiments revealed that this ginseng extract increased cell viability at a wide range of concentrations. Therefore, we investigated the effects of this extract on antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidases (GPx) and glutathione reductase (GR), on glutathione content (reduced and oxidized forms and red/ox index) and on the intracellular reactive oxygen species (ROS) formation. Exposure of astrocytes to H2O2 decreased the activities of antioxidant enzymes, and increased ROS formation. Ginseng root extract reversed the effect of almost all of these parameters in H2O2-injured primary cultures of rat astrocytes.
PB Elsevier
SN 0378-8741
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/117483
UL https://hdl.handle.net/20.500.14352/117483
LA eng
NO Naval, M. V., et al. «Neuroprotective Effect of a Ginseng (Panax Ginseng) Root Extract on Astrocytes Primary Culture». Journal of Ethnopharmacology, vol. 112, n.o 2, junio de 2007, pp. 262-70. DOI.org (Crossref), https://doi.org/10.1016/j.jep.2007.03.010
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 22 abr 2025