RT Journal Article
T1 On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen
A1 Khiari, Oussama
A1 Bouzemi, Nassima
A1 Sánchez Montero, José
A1 Alcántara León, Andrés Rafael
AB In this paper, we describe the effectiveness of the combination between an organic solvent system mixture with orthoformates with different chain sizes from one to four carbon atoms. These orthoesters have been used as a “water trapper/alcohol releaser molecule” to reach a notable improvement in enantioselectivity and enantiomeric excess of our target compound, (S)-2-(4-isobutylphenyl)propanoic acid (ibuprofen eutomer), during the enzymatic kinetic resolution of rac-ibuprofen using immobilized lipase B of Candida antarctica as a biocatalyst. At the same time, one of the great problems of biocatalysis in organic media has been solved by eliminating excess water in the medium that allows the reversibility of the reaction. Following the optimization of the reaction conditions, an increase in enantiomeric excess and enantioselectivity was reached by using these acyl donors in the presence of a cosolvent.
PB MDPI
SN 2073-4344
YR 2023
FD 2023-01-22
LK https://hdl.handle.net/20.500.14352/92528
UL https://hdl.handle.net/20.500.14352/92528
LA eng
NO Khiari, O.; Bouzemi, N.; Sánchez-Montero, J.M.; Alcántara, A.R. On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen. Catalysts 2023, 13, 251. https://doi.org/10.3390/catal13020251
NO Spanish Ministry of Science and Innovation
DS Docta Complutense
RD 6 oct 2024