RT Journal Article
T1 Effect of respiratory rehabilitation on quality of life in individuals with post-COVID-19 symptoms: A randomised controlled trial
A1 Del Corral Núñez-Flores, Tamara
A1 Fabero Garrido, Raúl
A1 Plaza Manzano, Gustavo
A1 Izquierdo García, Juan
A1 López Sáez, Mireya
A1 García García, Rocío
A1 López De Uralde Villanueva, Ibai Julio
AB BackgroundInspiratory and expiratory muscle training (RMT) has been shown to have beneficial effects in individuals with long-term post-COVID-19 symptoms.ObjectiveTo assess the effects of adding RMT to an aerobic exercise (AE) training program for health-related quality of life (HRQoL) and exercise tolerance in individuals with long-term post-COVID-19 symptoms, and to evaluate the effects on physical and lung function, and psychological status.Methods64 individuals with long-term post-COVID-19 symptoms of fatigue and dyspnoea were randomly assigned to AE+RMT or AE+RMTsham groups for an 8-wk intervention (AE: 50min/day, 2 times/wk; RMT: 40min/day, 3 times/wk). Primary outcomes were HRQoL (EuroQol-5D questionnaire) and exercise tolerance (cardiopulmonary exercise test). Secondary outcomes were physical function: respiratory muscle function (inspiratory/expiratory muscle strength and inspiratory muscle endurance), lower and upper limb strength (1-min Sit-to-Stand and handgrip force); lung function: spirometry testing and lung diffusing capacity; and psychological status (anxiety/depressive levels).ResultsPostintervention, there were no statistically significant improvements in HRQoL or exercise tolerance in the AE+RMT compared with the AE+RMTsham group. In the AE+RMT group, large improvements in respiratory muscle function (d = 0.7 to 1.3) and low-moderate improvements in peak expiratory flow (d = 0.4) occurred compared with the AE+RMTsham group. Lung function outcomes, lower and upper limb strength and psychological status did not increase more in the AE+RMT group than in the AE+RMTsham group.ConclusionFor individuals with long-term post-COVID-19 symptoms, combining RMT with an AE training program resulted in improvements in respiratory muscle strength, inspiratory muscle endurance and peak expiratory flow; however, the differences between groups were not statistically significant for HRQoL, exercise tolerance, psychological distress, and lung diffusing capacity.Database registrationUnited States Clinical Trials Registry (NCT05597774)
PB Elsevier
YR 2025
FD 2025-02
LK https://hdl.handle.net/20.500.14352/114039
UL https://hdl.handle.net/20.500.14352/114039
LA eng
NO Del Corral, Tamara, et al. «Effect of Respiratory Rehabilitation on Quality of Life in Individuals with Post-COVID-19 Symptoms: A Randomised Controlled Trial». Annals of Physical and Rehabilitation Medicine, vol. 68, n.o 1, febrero de 2025, p. 101920. DOI.org (Crossref), https://doi.org/10.1016/j.rehab.2024.101920.
NO Asociacion profesional de fisoterapeutas de la Comunidad de Madrid (II Convocatoria de ayudas a la Investigación en Fisioterapia y afecciones Post-Covid [CovidPersistente])
DS Docta Complutense
RD 20 abr 2025