RT Journal Article
T1 Salmonella Typhimurium exploits inflammation to its own advantage in piglets
A1 Chirullo, Barbara
A1 Pesciaroli, Michele
A1 Drumo, Rosanna
A1 Ruggeri, Jessica
A1 Razzuoli, Elisabetta
A1 Pistoia, Claudia
A1 Petrucci, Paola
A1 Martinelli, Nicola
A1 Cucco, Lucilla
A1 Moscati, Livia
A1 Amadori, Massimo
A1 Magistrali, Chiara F
A1 Alborali, Giovanni L
A1 Pasquali, Paolo
AB Salmonella Typhimurium (S. Typhimurium) is responsible for foodborne zoonotic infections that, in humans, induce self-limiting gastroenteritis. The aim of this study was to evaluate whether the wild-type strain S. Typhimurium (STM14028) is able to exploit inflammation fostering an active infection. Due to the similarity between human and porcine diseases induced by S. Typhimurium, we used piglets as a model for salmonellosis and gastrointestinal research. This study showed that STM14028 is able to efficiently colonize in vitro porcine mono-macrophages and intestinal columnar epithelial (IPEC-J2) cells, and that the colonization significantly increases with LPS pre-treatment. This increase was then reversed by inhibiting the LPS stimulation through LPS antagonist, confirming an active role of LPS stimulation in STM14028-intracellular colonization. Moreover, LPS in vivo treatment increased cytokines blood level and body temperature at 4 h post infection, which is consistent with an acute inflammatory stimulus, capable to influence the colonization of STM14028 in different organs and tissues. The present study proves for the first time that in acute enteric salmonellosis, S. Typhimurium exploits inflammation for its benefit in piglets.
PB Frontiers Media
SN 1664-302X
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/35265
UL https://hdl.handle.net/20.500.14352/35265
LA eng
NO Unión Europea. FP7
NO Moncloa: Campus de Excelencia Internacional
DS Docta Complutense
RD 25 dic 2025