RT Journal Article
T1 Time-Dependent Changes in Muscle IGF1-IGFBP5-PAPP System after Sciatic Denervation
A1 Martín Velasco, Ana Isabel
A1 Moreno Rupérez, Álvaro
A1 Nebot Valenzuela, Elena
A1 Granado, Miriam
A1 Jaque, Daniel
A1 Nieto Bona, María Paz
A1 López-Calderón Barreda, Asunción
A1 Priego Cuadra, Teresa
AB Denervation-induced muscle atrophy is a frequent cause of skeletal muscle diseases. However, the role of the most important muscle growth factor, insulin-like growth factor (IGF-1), in this process is poorly understood. IGF-1 activity is controlled by six IGF-1 binding proteins (IGFBPs). In skeletal muscle, IGFBP-5 seems to have an important role in atrophic processes. Furthermore, pappalysins (PAPP-A) modulate muscle growth by increasing IGF-1 bioavailability through IGFBP cleavage. We aimed to study the time-dependent changes in the IGF1-IGFBP5-PAPP system and its regulators in gastrocnemius muscle after sciatic denervation. Gastrocnemius atrophy and overexpression of IGF-1 was observed from day 3 post-denervation. The proteolytic factors measured were elevated from day 1 post-denervation onwards. Expression of both IGFBP-5 and pappalysins were increased on days 1 and 3. Subsequently, on days 7 to 14 pappalysins returned to control levels while IGFBP-5 remained elevated. The ratio IGFBP-5/PAPP-A was correlated with the main proteolytic markers. All data suggest that the initial increase of pappalysins could facilitate the IGF-1 action on muscle growth, whereas their subsequent decrease could lead to further muscle wasting.
PB MDPI
SN 1422-0067
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/88991
UL https://hdl.handle.net/20.500.14352/88991
LA eng
NO : Martín, A.I.; Moreno-Rupérez, Á.; Nebot, E.; Granado, M.; Jaque, D.; Nieto-Bona, M.P.; López-Calderón, A.; Priego, T. Time-Dependent Changes in Muscle IGF1-IGFBP5-PAPP System after Sciatic Denervation. Int. J. Mol. Sci. 2023, 24, 14112. https://doi.org/ 10.3390/ijms241814112
NO European Commission 
NO Ministerio de Economía y Competitividad (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 8 abr 2025