RT Journal Article
T1 Exudative epidermitis by Staphylococcus hyicus producing ExhC: control proposals against an emergent pathogen in intensive pig production
A1 Romero Salmoral, Antonio
A1 Álvarez Delgado, Carmen
A1 Muñoz Jiménez, Rafael A.
A1 Barraza, Paula
A1 Vela Alonso, Ana Isabel
A1 Fernández-Garayzábal Fernández, José Francisco
A1 Gómez Laguna, Jaime
A1 Luque, Inmaculada
A1 Tarradas, Carmen
AB Exudative epidermitis (EE) is an occasional infectious disease affecting suckling and weaned piglets, with severe presentation in outbreaks. We described the diagnosis and control measurements conducted after an outbreak of EE caused by Staphylococcus hyicus producing an exfoliative toxin type C (ExhC) in a commercial 4000-head sow farm. Clinical disease was observed in suckling piglets, with a 70 % of morbidity, and a significant increase of mortality rate of 5 % during this period (p < 0.0001) was detected. The bacteria could be recovered from skin and internal organs of affected animals, and the pulsed-field gel electrophoresis (PFGE) analysis showed that all the isolates were genetically indistinguishable, suggesting a common origin. Certain deficiencies in the cleaning and disinfection protocols carried out in the farrowing unit could be responsible for the severity of the outbreak. The efficacy of autogenous vaccination in sows with an inactivated vaccine based on complete ExhC-positive S. hyicus isolates at five and two weeks before farrowing in combination with the improvement of managements measures and selection of healthy animals for replacement allowed the resolution of the outbreak, completely reducing the morbidity and mortality rates after three months. The importance of an adequate diagnosis, biosecurity evaluation and the use of appropriate immune prophylaxis based on autogenous vaccines, are essential tools for the rapid and effective resolution of disease outbreaks of EE.
PB Elsevier
SN 1090-0233
YR 2025
FD 2025-03
LK https://hdl.handle.net/20.500.14352/119172
UL https://hdl.handle.net/20.500.14352/119172
LA eng
NO Romero-Salmoral A., Alvarez-Delgado C., Munoz-Jimenez RA., Barraza P., Vela AI., Fernandez-Garayzabal JF., Gomez-Laguna J., Luque I* and Tarradas C.(2025) Exudative epidermitis by Staphylococcus hyicus producing ExhC: Control proposals against an emergent pathogen in intensive pig production. The Veterinary Journal, 311:106338.(A). ISSN: 1090-0233. Impact factor 2023: 2.300. Category: Veterinary Sciences, Quartile: 1, Position: 28 of 167. DOI: 10.1016/j.tvjl.2025.106338
NO Credit authorship contribution statementLuque Inmaculada: Writing – review & editing, Writing – original draft, Visualization, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation, Conceptualization. Romero-Salmoral Antonio: Writing – review & editing, Methodology, Investigation, Data curation. Barraza Paula: Writing – review & editing, Methodology, Data curation. Vela Ana I.: Writing – review & editing, Methodology, Investigation, Formal analysis, Conceptualization. Álvarez-Delgado Carmen: Writing – review & editing, Methodology, Investigation, Data curation. Muñoz-Jiménez Rafael A.: Writing – review & editing, Methodology, Formal analysis, Data curation. Tarradas Carmen: Writing – review & editing, Supervision, Investigation, Funding acquisition, Formal analysis, Data curation, Conceptualization. Fernández-Garayzábal José Francisco: Writing – review & editing, Formal analysis, Data curation. Gómez-Laguna Jaime: Writing – review & editing, Methodology, Investigation, Formal analysis, Data curation
DS Docta Complutense
RD 5 abr 2025