RT Journal Article
T1 Neutrophils and neutrophil extracellular trap components: Emerging biomarkers and therapeutic targets for age-related eye diseases
A1 Martínez Alberquilla, Irene
A1 Gasull, Xavier
A1 Pérez Luna, Patricia
A1 Seco Mera, Rubén
A1 Ruiz Alcocer, Javier
A1 Crooke Álvarez, Almudena
AB Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy, represent a major global health issue based on their increasing prevalence and disabling action. Unraveling the molecular mechanisms underlying these diseases will provide novel opportunities to reduce the burden of age-related eye diseases and improve eye health, contributing to sustainable development goals achievement. The impairment of neutrophil extracellular traps formation/degradation processes seems to be one of these mechanisms. These traps formed by a meshwork of DNA and neutrophil cytosolic granule proteins may exacerbate the inflammatory response promoting chronic inflammation, a pivotal cause of age-related diseases. In this review, we describe current findings that suggest the role of neutrophils and their traps in the pathogenesis of the above-mentioned age-related eye diseases. Furthermore, we discuss why these cells and their constituents could be biomarkers and therapeutic targets for dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy. We also examine the therapeutic potential of some neutrophil function modulators and provide several recommendations for future research in age-related eye diseases.
PB Elsevier
SN 1568-1637
YR 2022
FD 2022-12-23
LK https://hdl.handle.net/20.500.14352/71307
UL https://hdl.handle.net/20.500.14352/71307
LA eng
NO Martínez Alberquilla, I., Gasull, X., Pérez Luna, P. et al. «Neutrophils and Neutrophil Extracellular Trap Components: Emerging Biomarkers and Therapeutic Targets for Age-Related Eye Diseases». Ageing Research Reviews, vol. 74, febrero de 2022, p. 101553. DOI.org (Crossref), https://doi.org/10.1016/j.arr.2021.101553.
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Instituto de Salud Carlos III
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Generalitat de Catalunya
NO Universidad Complutense de Madrid - Banco de Santander
DS Docta Complutense
RD 11 may 2025