RT Journal Article
T1 Unraveling the potential of bioadhesive antimicrobial microparticles for the treatment of prosthetic joint infections
A1 Sanz Ruiz, Pablo
A1 González Burgos, Elena María
A1 Serrano López, Dolores Remedios
A1 Luciano, Francis, C
A1 Yuste, Ivan
A1 Ribed-Sanchez, Almudena
A1 Ballesteros, Maria P.
A1 Rodríguez, C.
A1 Anayan, Brayan J.
A1 Tiboni, Mattia
A1 Maurizzi, Giorgia
A1 Casettari, Luca
AB Periprosthetic joint infections (PJIs) are serious complications following hip or knee arthroplasty, and current preventive and therapeutic strategies remain suboptimal due to inadequate antimicrobial efficacy. This study explores a novel approach for preventing and treating bacterial and fungal PJIs using smart bioadhesive microparticles obtained by spray drying and loaded with vancomycin (a broad-spectrum antibacterial) and amphotericin B (AmB, an antifungal). Dry microparticles were redispersed into a hyaluronic gel before adhesion to the prosthesis. The microparticles exhibited a sustained drug release profile, characterized by an initial burst release (40 %–80 % for AmB and vancomycin respectively) within the first 10 h, followed by prolonged release over seven days. The formulation demonstrated high efficacy against multiple pathogens, including Staphylococcus spp. (S. epidermidis and S. aureus) and Candida spp. (C. albicans, C. parapsilopsis, C. glabrata, and C. krusei). Additionally, the microparticles showed low hemolytic toxicity and provided a protective effect on mammalian cell lines (Saos-2, BJ, hFOB). These findings highlight a promising strategy for PJI prophylaxis and treatment, with potential for seamless integration into clinical practice.
PB Elsevier
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/120299
UL https://hdl.handle.net/20.500.14352/120299
LA eng
NO Luciano FC, Yuste I, Sanz-Ruiz P, Ribed-Sánchez A, Ballesteros MP, Rodríguez C, Anaya BJ, Tiboni M, Maurizzi G, Casettari L, González-Burgos E, Serrano DR. Unraveling the potential of bioadhesive antimicrobial microparticles for the treatment of prosthetic joint infections. Journal of Drug Delivery Science and Technology 2025;109:107001. https://doi.org/10.1016/j.jddst.2025.107001.
NO Ha recibido el apoyo de las ayudas de investigación ESCMID 2021 (16306).
NO Agencia Estatal de Investigación(España)
NO UCM
DS Docta Complutense
RD 14 jun 2025