RT Journal Article
T1 Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
A1 Sanz Gomez, María
A1 Zeng, Ni
A1 Catagna Catagna, Gloria Estefania
A1 Arribas Pardo, Paula
A1 García Feijoo, Julián
A1 Méndez Hernández, Carmen Dora
AB Background/Aims: Vascular factors are involved in the development of glaucoma, including diseases such as hypercholesterolemia (HC), systemic arterial hypertension (SAH), and diabetes mellitus (DM). The aim of this study was to determine the effect of glaucoma disease on peripapillary vessel density (sPVD) and macular vessel density (sMVD) on the superficial vascular plexus, controlling differences on comorbidities such as SAH, DM and HC between glaucoma patients and normal subjects. Methods: In this prospective, unicenter, observational cross-sectional study, sPVD and sMVD were measured in 155 glaucoma patients and 162 normal subjects. Differences between normal subjects and glaucoma patients’ groups were analyzed. A linear regression model with 95% confidence and 80% statistical power was performed. Results: Parameters with greater effect on sPVD were glaucoma diagnosis, gender, pseudophakia and DM. Glaucoma patients had a sPVD 1.2% lower than healthy subjects (Beta slope 1.228; 95%CI 0.798–1.659, p < 0.0001). Women presented 1.19% more sPVD than men (Beta slope 1.190; 95%CI 0.750–1.631, p < 0.0001), and phakic patients presented 1.7% more sPVD than men (Beta slope 1.795; 95%CI 1.311–2.280, p < 0.0001). Furthermore, DM patients had 0.9% lower sPVD than non-diabetic patients (Beta slope 0.925; 95%CI 0.293–1.558, p = 0.004). SAH and HC did not affect most of the sPVD parameters. Patients with SAH and HC showed 1.5% lower sMVD in the outer circle than subjects without those comorbidities (Beta slope 1.513; 95%CI 0.216–2.858, p = 0.021 and 1.549; 95%CI 0.240–2.858, p = 0.022 respectively. Conclusions: Glaucoma diagnosis, previous cataract surgery, age and gender seem to have greater influence than the presence of SAH, DM and HC on sPVD and sMVD, particularly sPVD.
PB MDPI
SN 2077-0383
YR 2023
FD 2023-02-06
LK https://hdl.handle.net/20.500.14352/72235
UL https://hdl.handle.net/20.500.14352/72235
LA eng
NO 1 Department of Inmunology Ophthalmology and ORL, IIORC, Complutense University of Madrid,28232 Madrid, Spain2 Ophthalmology Department, Central Defense Hospital “Gomez Ulla”, 28047 Madrid, Spain3 Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC),28232 Madrid, Spain
NO Department of Inmunology Ophthalmology and ORL, IIORC, Complutense University of Madrid, 28232 Madrid, Spain
NO Ophthalmology Department, Central Defense Hospital “Gomez Ulla”, 28047 Madrid, Spain
NO Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28232 Madrid, Spain
DS Docta Complutense
RD 28 abr 2024