RT Journal Article
T1 Overexpression of c-myc and loss of heterozigosity on 2p, 3p, 5q, 17p and 18q in sporadic colorectal carcinoma
A1 Cerdán, francisco Javier
A1 Morán, Alberto
A1 García Aranda, C
A1 Sánchez Pernaute, Andrés
A1 Pérez Aguirre, María Elia
A1 Iniesta Serrano, María Pilar
A1 Díez Valladares, Luis Ignacio
A1 Juan Chocano, María Del Carmen De
A1 García Botella, Alejandra María
A1 Benito De Las Heras, Manuel R.
A1 Torres García, Antonio José
A1 Balibrea Cantero, José Luis
AB Aim: the aim of the present study is to evaluate the prognostic influence of loss of heterozygosity on 2p, 3p, Sq, 17p and 18q, and c-myc overexpression on surgically treated sporadic colorectal carcinoma.Methods: tumor and non-tumor tissue samples from 153 patients were analyzed. Fifty-one percent of patients were mate, and mean age in the series was 67 years. Tumors were located in the proximal colon in 37 cases, in the distal bowel in 37, and in the rectum in 79 patients. c-myc overexpression was studied by means of Northern blot analysis, and loss of heterozygosity through microsatellite analysis.Results: c-myc overexpression was detected in 25% of cases, and loss of heterozygosity in at least one of the studied regions in 48%. There was no association between clinical and pathologic features, and genetic alterations. The disease-free interval was significantly shorter for patients with both genetic alterations; the presence of both events was an independent prognostic factor for poor outcome in the multivariate analysis (RR: 4.34, p < 0.0001).Conclusions: the presence of both loss of heterozygosity and overexpression of the c-myc oncogene separates a subset of colorectal carcinoma patients who have a shorter disease-free interval after curative-intent surgery.
PB Arán Ediciones
SN 1130-0108
YR 2005
FD 2005-03
LK https://hdl.handle.net/20.500.14352/117201
UL https://hdl.handle.net/20.500.14352/117201
LA eng
NO Sánchez-Pernaute A, Pérez-Aguirre E, Cerdán FJ, Iniesta P, Díez Valladares L, de Juan C, Morán A, García-Botella A, García Aranda C, Benito M, Torres AJ, Balibrea JL. Overexpression of c-myc and loss of heterozygosity on 2p, 3p, 5q, 17p and 18q in sporadic colorectal carcinoma. Rev Esp Enferm Dig. 2005 Mar;97(3):169-78. English, Spanish. doi: 10.4321/s1130-01082005000300005. PMID: 15943002
DS Docta Complutense
RD 5 abr 2025